2015年09月，清華大學教授施一公在Science同期發表2篇研究長文，被業界盛贊為“諾貝爾級成果”。同月出任清華大學副校長。
施一公，結構生物學家，中科院院士，美國兩院院士。1967年5月5日出生于河南省鄭州，1989年畢業于清華大學，1995年在美國約翰霍普金斯大學獲博士學位。主要從事細胞凋亡及膜蛋白兩個領域的研究。在Smad對TGF-?的調控機理、磷酸酶PP2A的結構生物學方面做出過有國際影響的工作。曾獲國際賽克勒生物物理學獎、香港求是科技基金會杰出科學家獎、談家楨生命科學終身成就獎、瑞典皇家科學院頒發的2014年度愛明諾夫獎等獎項。美國藝術與科學院院士、美國國家科學院外籍院士、歐洲分子生物學組織外籍成員。
除去不可計數的子刊，施一公在Nature、Science和Cell共發表54篇文章（截止時間2015.09.18，由于文章夠多，統計可能略有出入）。對此，小編我只能表示：嘖嘖嘖……
Cell正刊（21篇）
1. Structural Basis of RIP1 Inhibition by Necrostatins
2. Structural Insights into RIP3-Mediated Necroptotic Signaling
3. TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer
4. Structure and Mechanism of a Nitrate Transporter
5. A Glimpse of Structural Biology through X-Ray Crystallography
6. Crystal structure of the caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
7. Serine/Threonine Phosphatases: Mechanism through Structure
8. Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A
9. Allosteric Activation of a Bacterial Stress Sensor
10. Structure of the Protein Phosphatase 2A Holoenzyme
11. Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
12. PPM1A Functions as a Smad Phosphatase to Terminate TGFβ Signaling
13. Molecular mechanism of AHSP-mediated stabilization of α-hemoglobin
14. Caspase activation: Revisiting the induced proximity model
15. Mechanisms of TGF-β signaling from cell membrane to the nucleus
16. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
17. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-β signaling
18. Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding
19. Structural basis of caspase-7 inhibition by XIAP
20. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
21. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling
Nature正刊(23篇)
22. An atomic structure of human γ-secretase
23. Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA
24. Structure of a bacterial energy-coupling factor transporter
25. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution
26. Three-dimensional structure of human γ-secretase
27. Structural basis for the modular recognition of single-stranded RNA by PPR proteins
28. Structure of a presenilin family intramembrane aspartate protease
29. Structural basis of ultraviolet-B perception by UVR8
30. Structure and mechanism of a glutamate-GABA antiporter
31. Structure and mechanism of the hexameric MecA-ClpC molecular machine
32. Structure and mechanism of the S component of a bacterial ECF transporter
33. Mechanism of substrate recognition and transport by an amino acid antiporter
34. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel
35. Chaperone-mediated pathway of proteasome regulatory particle assembly
36. Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms
37. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
38. Structure of oxidized α-haemoglobin bound to AHSP reveals a protective mechanism for haem
39. Structure of the apoptotic protease-activating factor 1 bound to ADP
40. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
41. Structural basis of IAP recognition by Smac/DIABLO
42. Structural and biochemical basis of apoptotic activation by Smac/DIABLO
43. Structural basis of procaspase-9 recruitment by the apoptotic protease- activating factor 1
44. A structural basis for mutational inactivation of the tumour suppressor Smad4
Science(10篇)
45. Structure of a yeast spliceosome at 3.6-angstrom resolution
46. Structural basis of pre-mRNA splicing
47. Structural basis for sequence-specific recognition of DNA by TAL effectors
48. China's research culture
49. Structure and mechanism of an amino acid antiporter
50. Structure of a site-2 protease family intramembrane metalloprotease
51. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans
52. Structural basis of Smad2 recognition by the smad anchor for receptor activation
53. The galvanization of biology: A growing appreciation for the roles of zinc
54. Specific DNA-RNA hybrid binding by zinc finger proteins
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